The population of the United States is shaped by centuries of migration, isolation, growth, and admixture between populations of global origins. Here, we assemble a comprehensive view of recent population history by studying the ancestry and population structure of over 32,000 individuals in the US using genetic, ancestral birth origin, and geographic data. We identify migration routes and barriers that reflect historical demographic events. We also uncover the spatial patterns of relatedness in subpopulations through the combination of haplotype clustering, ancestral birth origin analysis, and local ancestry inference. These patterns include substantial structure and heterogeneity in Hispanics/Latinos, isolation-by-distance in African Americans, elevated levels of relatedness and homozygosity in Asian immigrants, and fine-scale structure in European descents. Furthermore, quantification of familial birthplaces recapitulates historical immigration waves at high resolution. Taken together, our results provide detailed insights into the genetic structure and demographic history of the diverse US population.
Significance Statement The population of the United States has globally diverse ancestors and a complex history. Despite previous studies of genetic diversity in the US, population history for many groups still remains ambiguous. Here, we study the DNA of over 32,000 US individuals who participated in the National Geographic Genographic Project. By combining analyses of migration, haplotype sharing, and ancestral birthplaces, we reconstruct demographic histories at fine-scale resolution. Among European Americans, Hispanics/Latinos, and African Americans, we disentangle patterns of immigration, within-country migration, and admixture. We also characterize the typically overlooked population history of Asian Americans. Overall, this study sheds light on the complex population histories detailed in the DNA of people living in the US.
- Dai, C.L., Vazifeh, M.M., Yeang, C.H., Tachet, R., Vilar, M.G., Daly, M.J., Ratti, C. and Martin, A.R. (2019). Population histories of the United States revealed through fine-scale migration and haplotype analysis. Biorxiv, -, 577411+.
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