Italy - Moyan Brenn

Phylogenetic Structure of Q-M378 Subclade Based On Full Y-Chromosome Sequencing

Phylogenetic Structure of Q-M378 Subclade Based On Full Y-Chromosome Sequencing

Abstract:

Q-M378 subclade, which is downstream of Q-L275 haplogroup, is marked by a wide area of its distribution and a minor share of presence in modern populations of Eurasia. Phylogenetic structure of the subclade, known so far, did not allow for matching SNP Y-chromosomes to specific populations and to reconstruct possible direc-tions of their migrations in retrospect. The conducted research enabled us to form a consistent phylogenetic structure of Q-M378 subclade, validated by analysis of SNP and STR-markers, based on the data of full Y-chromosome sequencing using next generation sequencers. As part of the research, new phylogenetic levels of Q-Y2250 (downstream of Q-M378 and including Q-L301), Q-Y2220 (downstream of Q-L245), Q-Y2200 (downstream of Q-Y2220) were defined. SNPs, which, in the future, may possibly mark certain European and Asian subclusters of Q-Y2220 (including the Armenian subcluster), as well as separate branches of the Jewish cluster Q-Y2200, were defined as well. The research also confirmed connection of Q-M378 subclade distribution with migration of Indo-European language carriers from Central Asia via Afghanistan and Iran to the West.

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Keywords

Peoples: Indo-European language carriers | Places: Central Asia | Topics: | DNA Type: Y-DNA

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