MitoTool: a web server for the analysis and retrieval of human mitochondrial DNA sequence variations

//MitoTool: a web server for the analysis and retrieval of human mitochondrial DNA sequence variations

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MitoTool: a web server for the analysis and retrieval of human mitochondrial DNA sequence variations

MitoTool: a web server for the analysis and retrieval of human mitochondrial DNA sequence variations

Abstract:

MitoTool, a web-based bioinformatics platform, is designed for deciphering human mitochondrial DNA (mtDNA) data in batch mode. The platform has advantages in (i) parsing diverse types of mtDNA data; (ii) automatically classifying haplogroup according to mtDNA sequences or variants; (iii) discovering possibly missing variants of the samples with claimed haplogroups status; (iv) estimating the evolutionary conservation index, protein coding effect and potential pathogenicity of certain substitutions; (v) performing statistical analysis for haplogroup distribution frequency between case and control groups. Furthermore, it offers an integrated database for retrieving five types of mitochondrion-related information. The MitoTool is freely accessed at http://www.mitotool.org.

Citation:

  • Fan, L., & Yao, Y. G. (2011). MitoTool: a web server for the analysis and retrieval of human mitochondrial DNA sequence variations. Mitochondrion, 11(2), 351-356.

Source Link:
http://www.sciencedirect.com/science/article/pii/S1567724910001686

Keywords

Peoples: | Places: | Topics: | DNA Type: mtDNA

2016-06-24T03:26:50+00:00 June 22nd, 2016|