Genetic analysis of 17 biallelic markers on Y chromosome in 3 Chinese ethnic group populations

Genetic analysis of 17 biallelic markers on Y chromosome in 3 Chinese ethnic group populations

Abstract:

OBJECTIVE:
To study the genetic polymorphism of Y chromosome in different Chinese ethnic group populations.
METHODS:
Genotypes of 17 biallelic markers located in the nonrecombining portion of the Y chromosome in 76 men from 3 Chinese ethnic group populations (Han in Shandong, Bai in Yunnan, and Tu in Qinghai) were examined with polymerase chain reaction (PCR) and allelic-specific PCR (ASPCR). Their haplotypes made of these 17 binary markers were constructed. The principle component (PC) analysis was conducted based on the haplotype frequency distribution among these 3 and other 15 published Chinese ethnic group populations.
RESULTS:
The diversities of M50, M110, M103, M88, M3, and M7 were not found in these 3 populations. The frequencies of YAP+ were 23.8%, 6.7%, and 4% respectively in Tu, Bai, and Shandong Han. Eleven haplotypes were found in 3 populations–7 haplotypes (H1, H3, H5, H6, H8, H9, and H11) in Shandong Han (Han.SD), 8 haplotypes (H1, H2, H3, H5, H6, H8, H11, and H16) in Tu, and 9 haplotypes (H1, H3, H4, H5, H6, H8, H9, H11, and H13) in Bai. The predominant haplotypes were H1, H3, H5, H6, H8, and H11. According to PC analysis, Bai was close to Northern Han; Shandong Han, Southern Han (Han.S), Bai and Yunnan Tibetan clustered together; and Tu was close to Yi, Hui and Manchurian.
CONCLUSIONS:
Shandong Han may have had genetic exchanges with southern populations in China. It has been confirmed that some gene components of Han had flowed into Bai’s gene pool. Gene flowed from Central Asia had impacted Chinese western populations.

Citation:

Source Link:
http://www.ncbi.nlm.nih.gov/pubmed/15562768

Keywords

Peoples: - | Places: - | Topics: - | DNA Type: Y-DNA

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