//Comprehensive Mutation Analysis of 53 Y-STR Markers in Father-Son Pairs

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Comprehensive Mutation Analysis of 53 Y-STR Markers in Father-Son Pairs

Comprehensive Mutation Analysis of 53 Y-STR Markers in Father-Son Pairs

Abstract:

The knowledge of mutation rate at Y-STR markers is essential in forensic casework, especially kinship genetic studies. In the present study, one hundred father–son pairs from Chinese Han population were typed with 53 Y STR markers (38 conventional markers and 15 rapidly mutating markers). A total of 28 mutations were detected in 6201 allele transfers. All were one-step mutation. The average estimated mutation rate of 15 rapidly mutating (RM) Y-STRs was 1.05 × 10−2 (95% CI 5.45 × 10−3–1.39 × 10−2), while the average mutation rate of 38 conventional Y-STRs was 1.46 × 10−3 (95% CI 3.07 × 10−4–2.59 × 10−3). In summary, the average mutation rate of 15 RM Y-STRs seemed to be seven times higher than that of 38 conventional Y-STRs.

Citation:

Source Link:
http://www.fsigeneticssup.com/article/S1875-1768(17)30202-0/abstract

Keywords

Peoples: - | Places: - | Topics: AGCU database Y24, AGCU Y SUPP, Mutation rate, Rapidly mutating Y-STRs (RM Y-STRs), and Y-STRs | DNA Type: Y-DNA

2017-09-16T18:53:04+00:00September 16th, 2017|