Clustering of 770,000 genomes reveals post-colonial population structure of North America

Clustering of 770,000 genomes reveals post-colonial population structure of North America

Abstract:

Despite strides in characterizing human history from genetic polymorphism data, progress in identifying genetic signatures of recent demography has been limited. Here we identify very recent fine-scale population structure in North America from a network of over 500 million genetic (identity-by-descent, IBD) connections among 770,000 genotyped individuals of US origin. We detect densely connected clusters within the network and annotate these clusters using a database of over 20 million genealogical records. Recent population patterns captured by IBD clustering include immigrants such as Scandinavians and French Canadians; groups with continental admixture such as Puerto Ricans; settlers such as the Amish and Appalachians who experienced geographic or cultural isolation; and broad historical trends, including reduced north-south gene flow. Our results yield a detailed historical portrait of North America after European settlement and support substantial genetic heterogeneity in the United States beyond that uncovered by previous studies.

Citation:

  • Han, E., Carbonetto, P., Curtis, R.E., Wang, Y., Granka, J.M., Byrnes, J., Noto, K., Kermany, A.R., Myres, N.M., Barber, M.J., Rand, K.A., Song, S., Roman, T., Battat, E., Elyashiv, E., Guturu, H., Hong, E.L., Chahine, K.G. & Ball, C.A. (2017). Clustering of 770,000 genomes reveals post-colonial population structure of North America. Nature Communications, 8(14238), 14238+.

Source Link:
http://www.nature.com/articles/ncomms14238

Keywords

Peoples: African Americans and North American | Places: Americas | Topics: IBD | DNA Type: Autosomal DNA

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