////Q-M242 Weekly Update – 10 July 2018

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Q-M242 Weekly Update – 10 July 2018

Hi,

This is Rebekah Canada from the Y-DNA Haplogroup Q-M242 Project. This week's newsletter will cover the project's most recent published paper, the Q-L804 and Q-L527 branches, and new SNP Packs being developed by Family Tree DNA for Q-L804 and Q-L527.

New Paper

The project's most recent research collaboration is published. We are most grateful to those who donated their test results, Michael Sager and Brent Manning in the FTDNA lab, our colleges in China, and the reviewers and publishers for the European Journal of Human Genetics.

Paternal origin of Paleo-Indians in Siberia: insights from Y-chromosome sequences

Abstract: The expansion of modern humans to the American continent after the Last Glacial Maximum led the way to the present-day distribution of American aborigines. Recent advances in autosomal DNA research and expanded testing of mtDNA lineages has provided a clearer picture of the number and timing of founding lineages. However, both autosomal DNA and mtDNA research have provided unresolved competing theories between the short-term and the long-term models of the Beringian standstill hypothesis. Further, the source of founding paternal lineages of American aborigines and their relationship with ancient Siberia populations remains ambiguous. In this study, we reanalyzed a 7.0 Mbp region of 132 paternal Y-chromosome sequences, including 39 newly reported ones, of male samples from American aborigines and Eurasian populations. Among Eurasian samples, we identified Y-chromosome branches that are most closely related to known American aborigine founding lineages, that is, Q1-L804 links to Q1-M3, Q1-L330 links to Q1-Z780, Q1-M120 links to Q1-B143, and C2-F1756 links to C2-P39. The revised phylogenetic tree and age estimates indicate a narrow timeframe (~15.3–14.3 kya) for the upper time limit of human entry to the American continent. Our analysis suggests that the in situ differentiation of Q-M242 in Central Eurasia and South Siberia region gave rise to numerous sub-lineages older than 15.3 kya, and the founding of Paleo-Indian paternal lineages is part of the great Q1-L53 diffusion throughout the Eurasia after the Last Glacial Maximum. The results of our study will assist in future studies of the history of modern populations in Eurasia and the Americas.

Journal Website: https://www.nature.com/articles/s41431-018-0211-6

Q-L527 and Q-L804 Overview

Q-L527 and Q-L804 are two Northwestern European branches of Q. A brother branch to the major Native American founding Q-M3 lineage, Q-L804's presence in Europe is fascinating. On the other hand, the perhaps older Q-L527 ties into the Q-L940 branch that links it broadly to Southwestern Asia and the Middle East. Many people guess that if someone is a European Q then they must be either one or the other of these branches. This is not the case.

It is most rare to find either of these branches outside of Norway, Sweden, and the British Isles. If you are a German Q, you are likely a much different branch. To make things even more complicated, though both have their highest frequencies in the West of Sweden, their oldest and most divers branches may be from England in the British Isles.

It is exploring the distribution of the branches under Q-L527 and Q-L804 that has inspired the creation of mini-SNP Packs for each.

Q-L527 Tree

Q-L527 July 10 2018

Q-L804 Tree

Q-L804 July 10 2018

New SNP Packs

As a reminder, a SNP Pack is a preset group of Y-DNA SNPs that are ordered and tested together. This eliminates guess-work in testing and greatly reduces the price per Y-SNP tested. The Q-L527 and Q-L804 branches have enjoyed extensive Big Y testing, but broader testing of men from diverse geographic origins is needed to help expand what is known of the lineages under these two branches. Thus, in April, I decided that the project was ready to work on two new SNP Packs. I contacted Michael Sager at Family Tree DNA, and we agreed on two small low-cost SNP Packs.

Me: What do you think of doing single well panels (<40 SNPs) for Q-L804 and Q-L527? Those are the branches most common to the Swedes and the English. (April 19)
Michael Sager: This is probably something we could entertain. We can look at a SNP list and go from there. (April 23)
Me: Would you be willing to double-check those two branches (they are small) for completeness on the tree? I think we are completely current, but I would feel better if you looked at it. (April 23)
Michael Sager: I believe both branches are now fully up to date with the in-house data we have.
Me: Thanks. For Q-L804, we would have these, plus maybe 10 more that you think would be useful for redundancy? I grabbed primary SNPs, but feel free to go with any SNP on a branch that would work better on the panel. (April 23)

I would say that Q-L804 is 2 to 3% of Norway and Sweden and is lower frequency in Iceland, Finland, and the British Isles.
Me: Correction. Not found in Finland yet, that is Q-L527. (April 23)
Me: Q-L527 is a little tighter, but I think we can still do it. I grabbed primary SNPs, but feel free to go with any SNP on a branch that would work better on the panel.

I would say that Q-L527 is also 2 to 3% of Norway and Sweden. It is found in Finland and the British Isles. I suspect it would be found more in some part of Western Central Asia if we got customers from the right place. (April 23)
Michael Sager: Ok – I will have something for you relatively soon I start with the current SNP lists and see if any need to go. (April 25)
Michael Sager: Just a note on this, we have ordered this panel. We expect it to arrive this week or late next week. At which point we'll get validations going shortly there after. (June 13)
Michael Sager: For the most part these panels came back with pretty nice data. … (July 6)
Me: Sounds good. (July 6)

The Panels

Here is what the panels will test. They are not perfect, but I think they came out really well. They will be available to order in the next two weeks. I will email those who I believe will most benefit from them.

Q-L527

SNP MarkerBranchWorking
L527Q-L527Yes
Y4838Q-Y4838Yes
Y15684Q-Y15684Yes
Y15682Q-Y15682Yes
Y15683Q-Y15683Yes
Y17427Q-Y17427Yes
BZ50069Q-BZ50069Yes
FGC6872Q-BZ50069Yes
FGC6986Q-FGC6986Yes
YP5085Q-FGC6986Yes
BY38337Q-YP5085Yes
BY38336Q-BY38336Yes
Y105256Q-BY38336Yes
Y11649Q-Y105256Yes
Y103147Q-Y11649Yes
BY50206Q-BY38339Yes
BY50207Q-BY50206Yes
Y16739Q-BY50206Yes
BY15847Q-Y16739Yes
YP4798Q-BY15847Yes
BY15842Q-YP4798Yes
BY15843Q-BY15842Yes
YP4568Q-BY15843Yes
Y17593Q-YP4568Yes
BY40610Q-Y17593Yes
BY40729Q-BY40610Yes
BZ4900Q-BY40728Yes
YP5094Q-BZ4899Yes
YP5093Q-YP5093Yes
BY38345Q-YP5093Yes
Y59819Q-BY38345Yes
BZ50006Q-Y59819Yes
BZ50018Q-BZ50006Maybe
BZ50019Q-BZ50018Yes
FGC6995Q-BZ50018Yes
Y17427Q-FGC6995Maybe
Y29862Q-Y17427Yes
Y44561Q-Y44561Yes
Y4929Q-Y4929Yes
YP4801Q-YP4801Yes

Q-L804

SNP MarkerBranchWorking
BY15789Q-BY15789No
BY15796Q-BY15796Yes
BY38347Q-BY38347Yes
BY387Q-BY387Yes
BY459Q-BY459Yes
BY15790Q-BY460Yes
BY460Q-BY460Yes
BZ4901Q-BZ4901Yes
BZ4910Q-BZ4901Yes
BZ50007Q-BZ50007Yes
BZ50009Q-BZ50007Yes
JN14Q-JN14Yes
L804Q-L804Yes
L807Q-L807Yes
PH2989Q-L807Yes
M7839Q-M7839Yes
PH223Q-PH2487Yes
PH2487Q-PH2487Yes
Y11515Q-Y11515Yes
Y15622Q-Y15622Yes
Y15700Q-Y15700Yes
A13513Q-Y16137Yes
Y16137Q-Y16137Yes
Y18021Q-Y18021Yes
Y18220Q-Y18220Yes
Y18503Q-Y18503Yes
Y22488Q-Y22488Yes
Y22489Q-Y22489No
Y29863Q-Y29863Yes
Y38488Q-Y38488Yes
Y39585Q-Y38488Yes
Y38666Q-Y38666Yes
Y44444Q-Y38666Yes
Y39131Q-Y39131Maybe
Y39131Q-Y39131Yes
Y9048Q-Y9050No
Y9291Q-Y9291Yes
Y9294Q-Y9291Yes
YP4709Q-YP4709Yes
YP5097Q-YP5097Yes

Jewish Q News

Last week's newsletter for Jewish Q included an overview of Q-Y2232.


Regards,
Rebekah A. Canada
Volunteer Administrator, Family Tree DNA

2018-07-11T13:27:42+00:00July 10th, 2018|Categories: Q-M242|
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