Sex-specific genetic diversity is shaped by cultural factors in Inner Asian human populations

We sampled DNA in Central and Northern Asia from 39 populations of Indo-Iranian and Turkic-Mongolic native speakers. This study highlights that, in Inner Asia, specific cultural behaviors, especially patrilineality and patrilocality, leave a detectable signature on the sex-specific genetic structure.

2017-02-07T16:41:42+00:00February 7th, 2017|

A recent bottleneck of Y chromosome diversity coincides with a global change in culture

Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192–307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47–52 kya...

2016-12-11T19:07:50+00:00October 28th, 2016|

A

Haplogroup A is a branch on the maternal tree of human kind. It is a child of major haplogroup N. It was likely born in East Asia around 24,000 years ago. (Behar et al., 2012b). Through historic travels, members of this line live across East Asia and the Americas.

2018-10-06T21:51:56+00:00June 6th, 2016|

117 Asian mitochondrial DNA (mtDNA) lineage F4 is associated with increased risk of developing metabolic syndrome

Since we first linked mtDNA mutations to Type II diabetes(T2DM) in a family study (Ballinger, S. et al., Nat. Genet. 1, 11–15), increasing evidence has accumulated implicating mtDNA variation in the etiology of T2DM and the metabolic syndrome (MS). Functional mtDNA variation includes both recent inherited mutations but also ancient adaptive polymorphisms encompassed within region-specific mtDNA lineages (haplogroups) (Ruiz-Pesini, E .et al.,2004. Science 303, 223–226). To determine if ancient mtDNA haplogroups might also influence risk for T2DM and MS, we studied 989 subjects from Taiwan which had been evaluated for T2DM & MS.

2016-06-10T08:59:44+00:00December 31st, 2010|
Do NOT follow this link or you will be banned from the site!