We prepared a next generation sequencing (NGS)-based target sequencing panel of 85 Y-SNPs to determine Y-haplogroup of Asian populations.
We sampled DNA in Central and Northern Asia from 39 populations of Indo-Iranian and Turkic-Mongolic native speakers. This study highlights that, in Inner Asia, specific cultural behaviors, especially patrilineality and patrilocality, leave a detectable signature on the sex-specific genetic structure.
Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192–307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47–52 kya...
We review studies of genomic data obtained by sequencing hominin fossils with particular emphasis on the unique information that ancient DNA (aDNA) can provide about the demographic history of humans and our closest relatives. We concentrate on nuclear genomic sequences that have been published in the past few years....
Haplogroup A is a branch on the maternal tree of human kind. Its age is between 19,300 and 29,100 years (Behar et al., 2012b).
117 Asian mitochondrial DNA (mtDNA) lineage F4 is associated with increased risk of developing metabolic syndrome
Since we ﬁrst linked mtDNA mutations to Type II diabetes(T2DM) in a family study (Ballinger, S. et al., Nat. Genet. 1, 11–15), increasing evidence has accumulated implicating mtDNA variation in the etiology of T2DM and the metabolic syndrome (MS). Functional mtDNA variation includes both recent inherited mutations but also ancient adaptive polymorphisms encompassed within region-speciﬁc mtDNA lineages (haplogroups) (Ruiz-Pesini, E .et al.,2004. Science 303, 223–226). To determine if ancient mtDNA haplogroups might also inﬂuence risk for T2DM and MS, we studied 989 subjects from Taiwan which had been evaluated for T2DM & MS.