Summary

Age: 6,448.0 ± 1,210.9; CI=95% (Behar et al., 2012b)
Origin: Undetermined
Mutations: T477C
Parent Branch: H1
Descendant branch(s): H1c1 H1c10 H1c11 H1c12 H1c13 H1c14 H1c15 H1c16 H1c17 H1c18 H1c19 H1c2 H1c20 H1c21 H1c22 H1c3 H1c4 H1c5 H1c6 H1c7 H1c8 H1c9

Background

Haplogroup H1c is a branch on the maternal tree of human kind. The woman who founded this line lived between 5,200 and 7,700 years ago (Behar et al 2012b).

mtDNA Haplogroup H1c Phylotree History

Phylotree.org is the maternal (mtDNA) tree of humanity. It is maintained by Dr. Mannis Van Oven. Each build is a major update to the tree. The current build is #17.

mtDNA Haplogroup H1c Data Sources

GenBank Samples

GenBank is a database of genetic sequence data. It is run by the United States National Institute of Health. It serves as the main repository for mtDNA full sequence profiles. Samples come both from published academic literature and donations from genetic genealogy community members. In addition to GenBank samples, listings below may include other samples published but not submitted to GenBank such as those from the HapMap project.

Note: GenBank results currently use Phylotree build 16. I am working on changing resuts over to build 17.

Geno 2.0 Data

Data from Geno 2.0 is derived from the The National Geographic Society’s Genographic Project — the DAR. The Hg ID is specific to this site and is used to protect the identities of those who take part in Genographic research. Birth Country, Mother's Birth Country, and Maternal Grandmother's Birth Country have been normalized from DAR database fields. The Maternal Origin is determined based on the three previous fields.

Note: Geno 2.0 results currently use Phylotree build 16. I am working on changing resuts over to build 17.

If you use the information in this table, please credit both this site and The National Geographic Society’s Genographic Project.

Sources & Resources

Related Sources

• Behar, D.M., Harmant, C., Manry, J., van Oven, M., Haak, W., Martinez-Cruz, B., Salaberria, J., Oyharçabal, B., Bauduer, F., Comas, D. and Quintana-Murci, L. (2012). The Basque Paradigm: Genetic Evidence of a Maternal Continuity in the Franco-Cantabrian Region since Pre-Neolithic Times. American journal of human genetics, 90(3), 486-493.
• Behar, D.M., van Oven, M., Rosset, S., Metspalu, M., Loogväli, E.L., Silva, N.M., Kivisild, T., Torroni, A. and Villems, R. (2012). A “Copernican” reassessment of the human mitochondrial DNA tree from its root. American journal of human genetics, 90(4), 675-684.
• Fan, L., & Yao, Y. G. (2011). MitoTool: a web server for the analysis and retrieval of human mitochondrial DNA sequence variations. Mitochondrion, 11(2), 351-356.
• Fan, L., & Yao, Y. G. (2013). An update to MitoTool: using a new scoring system for faster mtDNA haplogroup determination. Mitochondrion, 13(4), 360-363.
• Gasparre, G., Porcelli, A.M., Bonora, E., Pennisi, L.F., Toller, M., Iommarini, L., Ghelli, A., Moretti, M., Betts, C.M., Martinelli, G.N. and Ceroni, A.R. (2007). Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors. Proceedings of the National Academy of Sciences, 104(21), 9001-9006.
• Hartmann, A., Thieme, M., Nanduri, L.K., Stempfl, T., Moehle, C., Kivisild, T. and Oefner, P.J. (2008). Validation of microarray-based resequencing of 93 worldwide mitochondrial genomes. Human mutation, 30(1), 115-122.
• Kloss-Brandstätter, A., Schäfer, G., Erhart, G., Hüttenhofer, A., Coassin, S., Seifarth, C., Summerer, M., Bektic, J., Klocker, H. and Kronenberg, F. (2010). Somatic Mutations throughout the Entire Mitochondrial Genome Are Associated with Elevated PSA Levels in Prostate Cancer Patients. The American Journal of Human Genetics, 87(6), 802-812.
• Raule, N., Sevini, F., Li, S., Barbieri, A., Tallaro, F., Lomartire, L., Vianello, D., Montesanto, A., Moilanen, J.S., Bezrukov, V. and Blanché, H. (2014). The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific. Aging cell, 13(3), 401-407.
• Van der Walt, E.M., Smuts, I., Taylor, R.W., Elson, J.L., Turnbull, D.M., Louw, R. and van der Westhuizen, F.H. (2012). Characterization of mtDNA variation in a cohort of South African paediatric patients with mitochondrial disease. European Journal of Human Genetics, 20(6), 650-656.
• Van Oven, M., & Kayser, M. (2009). Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation. Human mutation, 30(2), E386-E394.

Additional Resources

• Ian Logan's mtDNA Pages
• Ian Logan's Instructions for mtGenome Genbank Donation
• James Lick's mtDNA Utility
• The FTDNA Haplogroup Project for Haplogroup H & HV
• The Wikipedia Article for Haplogroup H

mtDNA Consultants

The following members of the community offer paid consulting for those seeking help with mtDNA results. Inclusion on this list is not a recommendation or endorsement of any service.

• DNA Explorers – Robert Sliwinski
• Genetic Genealogy Consultant – Ugo Perego
• Your DNA Guide – Diahan Southard