Haplogroup M74a is a branch on the maternal tree of human kind. Its age is between 3,500 and 16,800 years (Behar et al., 2012b).
mtDNA Haplogroup M74a Phylotree History
Phylotree.org is the maternal (mtDNA) tree of humanity. It is maintained by Dr. Mannis Van Oven. Each build is a major update to the tree. The current build is #17.
|10||M74a||63 64 66 6185 6575 12850||Released 10 Aug 2010|
|11||M74a||63 64 66 6185 6575 12850 16381||Released 7 Feb 2011|
|12||M74a||63 64 66 6185 6575 12850 16381||Released 20 Jul 2011|
|13||M74a||63 64 66 6185 6575 12850 16381||Released 28 Dec 2011; Last Build to use the rCRS|
|14||M74a||T63C C64T G66A T6185C A6575G A12850G T16381C||Released 5 Apr 2012; First version to use the RSRS|
|15||M74a||T63C C64T G66A T6185C A6575G A12850G T16381C||Released 30 Sep 2012|
|16||M74a||T63C C64T G66A T6185C A6575G A12850G T16381C||Released 19 Feb 2014|
|17||M74a||T63C C64T G66A T6185C A6575G A12850G T16381C||Released 18 Feb 2016|
mtDNA Haplogroup M74a Data Sources
GenBank is a database of genetic sequence data. It is run by the United States National Institute of Health. It serves as the main repository for mtDNA full sequence profiles. Samples come both from published academic literature and donations from genetic genealogy community members. In addition to GenBank samples, listings below may include other samples published but not submitted to GenBank such as those from the HapMap project.
Note: GenBank results currently use Phylotree build 16. I am working on changing resuts over to build 17.
|Hg ID||Publication||Missing Variants||Additional Variants|
|Hap5015594||Zou et al., 2010||none||M74a:315.1C, 7861, 16274, 16519|
|Hap5017239||Kong et al., 2011||none||M74a:215, 315.1C, 523-524d, 12972, 14311, 15139, 16093, 16519|
|Hap5017511||Yang et al., 2012||M74a:12850||M74a:215, 315.1C, 397.1A, 523-524d, 14180, 14311, 16093, 16519|
Geno 2.0 Data
Data from Geno 2.0 is derived from the The National Geographic Society’s Genographic Project — the DAR. The Hg ID is specific to this site and is used to protect the identities of those who take part in Genographic research. Birth Country, Mother's Birth Country, and Maternal Grandmother's Birth Country have been normalized from DAR database fields. The Maternal Origin is determined based on the three previous fields.
Note: Geno 2.0 results currently use Phylotree build 16. I am working on changing resuts over to build 17.
If you use the information in this table, please credit both this site and The National Geographic Society’s Genographic Project.
Sources & Resources
- Behar, D.M., van Oven, M., Rosset, S., Metspalu, M., Loogväli, E.L., Silva, N.M., Kivisild, T., Torroni, A. and Villems, R. (2012). A “Copernican” reassessment of the human mitochondrial DNA tree from its root. American journal of human genetics, 90(4), 675-684.
- Fan, L., & Yao, Y. G. (2011). MitoTool: a web server for the analysis and retrieval of human mitochondrial DNA sequence variations. Mitochondrion, 11(2), 351-356.
- Fan, L., & Yao, Y. G. (2013). An update to MitoTool: using a new scoring system for faster mtDNA haplogroup determination. Mitochondrion, 13(4), 360-363.
- Kong, Qing-Peng; Sun, Chang; Wang, Hua-Wei; Zhao, Mian; Wang, Wen-Zhi; Zhong, Li; Hao, Xiao-Dan; Pan, Hui; Wang, Sha-Yan; Cheng, Yao-Ting; Zhu, Chun-Ling; Wu, Shi-Fang; Liu, Li-Na; Jin, Jie-Qiong; Yao, Yong-Gang & Zhang, Ya-Ping (2011). Large-Scale mtDNA Screening Reveals a Surprising Matrilineal Complexity in East Asia and Its Implications to the Peopling of the Region. Molecular Biology and Evolution, 28(1), 513-522.
- Van Oven, M., & Kayser, M. (2009). Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation. Human mutation, 30(2), E386-E394.
- Yang, X., Wang, X., Yao, H., Deng, J., Jiang, Q., Guo, Y., Lan, G., Liao, D.J. and Jiang, H. (2012). Mitochondrial DNA polymorphisms are associated with the longevity in the Guangxi Bama population of China. Molecular biology reports, 39(9), 9123-9131.
- Zou, Y., Jia, X., Zhang, A.M., Wang, W.Z., Li, S., Guo, X., Kong, Q.P., Zhang, Q. and Yao, Y.G. (2010). The MT-ND1 and MT-ND5 genes are mutational hotspots for Chinese families with clinical features of LHON but lacking the three primary mutations. Biochemical and biophysical research communications, 399(2), 179-185.
- Ian Logan's mtDNA Pages
- Ian Logan's Instructions for mtGenome Genbank Donation
- James Lick's mtDNA Utility
- The FTDNA Haplogroup Project for Haplogroup M
- The Wikipedia Article for Haplogroup M
The following members of the community offer paid consulting for those seeking help with mtDNA results. Inclusion on this list is not a recommendation or endorsement of any service.
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Last Updated: Last updated: November 30, -0001 at 0:00 am