FTDNA Sales Banner
Ads and affiliate links like this help support the Q-M242 project's efforts to test indigenous peoples. Please read the affiliateship and business disclaimers for details. You may also donate directly here.

TPH2 – A Gene

Summary

Chromosome: 12

Cytogenetic location: 12q21.1

Genomic coordinates (GRCh38): 12:71938845-72032440

Tryptophan hydroxylase 2 (TPH2) is a human gene. It codes for an isozyme. This is a type of enzyme. In humans, TPH2 is mainly expressed in our brains. It helps control serotonin synthesis in our brains. Serotonin is a chemical that helps regulate our moods.

TPH2 has been linked to many mental health related issues. These include major depression, Bipolar depression, suicide risk, ADHD, schizophrenia, autism, addiction, anxiety disorders, tic disorders, eating disorders, borderline personality disorder, social anxiety disorder, and obsessive compulsive disorder.

Marker (SNP)Build 38 PositionVariantsTraits
rs457062571938143G/TObsessive compulsive disorders, Suicide, Schizophrenia, Depression, Bipolar disorder, ADHD
rs1117899771938373A/TSuicide, Schizophrenia, Depression, Bipolar disorder, ADHD
rs1117899871938935A/GDepression, Bipolar disorder
rs434158171941293G/TAutism
rs1074818571942075A/GDepression, Bipolar disorder
rs456594671942989C/TObsessive compulsive disorders
rs1117900071944848A/TAutism
rs212957571946293G/TAutism
rs184380971954918G/TSuicide, Depression, Bipolar disorder, ADHD
rs138649671957010A/G 
rs1087934671958055C/T 
rs138649471958763C/TSuicide, Depression, Bipolar disorder
rs138649371961399A/GADHD
rs217136371966484A/GDepression, Bipolar disorder
rs138649171968598C/G 
rs1711056371972526C/TBipolar disorder
rs730064171974791G/T 
rs1117902271976966A/G 
rs730511571979082A/GSuicide, Depression, Bipolar disorder
rs476075171984138A/G 
rs102399071988467A/G 
rs1050664571991720C/T 
rs100702371994594G/TAutism
rs138649771998510A/C 
rs1222939471999134A/G 
rs476082072003216C/GDepression, Bipolar disorder
rs138649872004363A/G 
rs148727872007071C/T 
rs1772213472007914A/G 
rs1117903972008406C/T 
rs148727672011279C/T 
rs932520272013697A/G 
rs1711069072014217A/G 
rs1223134172015656C/T 
rs1223135672015768C/T 
rs1087935472016002C/T 
rs1117905072016299A/G 
rs148727572016512A/CDepression, Bipolar disorder
rs138648672018440A/GDepression, Bipolar disorder
rs138648372018714C/T 
rs1087935772020783A/G 
rs1161501672022214A/G 
rs429027072022455A/TSuicide, Depression, Bipolar disorder
rs148727972025526A/T 
rs1117906472026271A/G 
rs1711074772032174A/GSuicide, Schizophrenia, Depression, Bipolar disorder, Addiction

Sources & Resources

General

Journal Articles

you're currently offline