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Summary
Chromosome: 12
Cytogenetic location: 12q21.1
Genomic coordinates (GRCh38): 12:71938845-72032440
Tryptophan hydroxylase 2 (TPH2) is a human gene. It codes for an isozyme. This is a type of enzyme. In humans, TPH2 is mainly expressed in our brains. It helps control serotonin synthesis in our brains. Serotonin is a chemical that helps regulate our moods.
TPH2 has been linked to many mental health related issues. These include major depression, Bipolar depression, suicide risk, ADHD, schizophrenia, autism, addiction, anxiety disorders, tic disorders, eating disorders, borderline personality disorder, social anxiety disorder, and obsessive compulsive disorder.
| Marker (SNP) | Build 38 Position | Variants | Traits |
|---|---|---|---|
| rs4570625 | 71938143 | G/T | Obsessive compulsive disorders, Suicide, Schizophrenia, Depression, Bipolar disorder, ADHD |
| rs11178997 | 71938373 | A/T | Suicide, Schizophrenia, Depression, Bipolar disorder, ADHD |
| rs11178998 | 71938935 | A/G | Depression, Bipolar disorder |
| rs4341581 | 71941293 | G/T | Autism |
| rs10748185 | 71942075 | A/G | Depression, Bipolar disorder |
| rs4565946 | 71942989 | C/T | Obsessive compulsive disorders |
| rs11179000 | 71944848 | A/T | Autism |
| rs2129575 | 71946293 | G/T | Autism |
| rs1843809 | 71954918 | G/T | Suicide, Depression, Bipolar disorder, ADHD |
| rs1386496 | 71957010 | A/G | |
| rs10879346 | 71958055 | C/T | |
| rs1386494 | 71958763 | C/T | Suicide, Depression, Bipolar disorder |
| rs1386493 | 71961399 | A/G | ADHD |
| rs2171363 | 71966484 | A/G | Depression, Bipolar disorder |
| rs1386491 | 71968598 | C/G | |
| rs17110563 | 71972526 | C/T | Bipolar disorder |
| rs7300641 | 71974791 | G/T | |
| rs11179022 | 71976966 | A/G | |
| rs7305115 | 71979082 | A/G | Suicide, Depression, Bipolar disorder |
| rs4760751 | 71984138 | A/G | |
| rs1023990 | 71988467 | A/G | |
| rs10506645 | 71991720 | C/T | |
| rs1007023 | 71994594 | G/T | Autism |
| rs1386497 | 71998510 | A/C | |
| rs12229394 | 71999134 | A/G | |
| rs4760820 | 72003216 | C/G | Depression, Bipolar disorder |
| rs1386498 | 72004363 | A/G | |
| rs1487278 | 72007071 | C/T | |
| rs17722134 | 72007914 | A/G | |
| rs11179039 | 72008406 | C/T | |
| rs1487276 | 72011279 | C/T | |
| rs9325202 | 72013697 | A/G | |
| rs17110690 | 72014217 | A/G | |
| rs12231341 | 72015656 | C/T | |
| rs12231356 | 72015768 | C/T | |
| rs10879354 | 72016002 | C/T | |
| rs11179050 | 72016299 | A/G | |
| rs1487275 | 72016512 | A/C | Depression, Bipolar disorder |
| rs1386486 | 72018440 | A/G | Depression, Bipolar disorder |
| rs1386483 | 72018714 | C/T | |
| rs10879357 | 72020783 | A/G | |
| rs11615016 | 72022214 | A/G | |
| rs4290270 | 72022455 | A/T | Suicide, Depression, Bipolar disorder |
| rs1487279 | 72025526 | A/T | |
| rs11179064 | 72026271 | A/G | |
| rs17110747 | 72032174 | A/G | Suicide, Schizophrenia, Depression, Bipolar disorder, Addiction |
Sources & Resources
General
- TPH2 Gene – GeneCards
- TPH2 gene – Genetics Home Reference – NIH
- TPH2 – Wikipedia
- TPH2 Gene – DNA Learning Center
Journal Articles
- Ottenhof, K.W., Sild, M., Lévesque, M.L., Ruhé, H.G. and Booij, L. (2018). TPH2 polymorphisms across the spectrum of psychiatric morbidity: A systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews, 92, 29-42.