//MtDNA evidence for a genetic bottleneck in the early history of the Ashkenazi Jewish population

MtDNA evidence for a genetic bottleneck in the early history of the Ashkenazi Jewish population

MtDNA evidence for a genetic bottleneck in the early history of the Ashkenazi Jewish population

Author(s): Behar, D.M., Hammer, M.F., Garrigan, D., Villems, R., Bonne-Tamir, B., Richards, M., Gurwitz, D., Rosengarten, D., Kaplan, M., Della Pergola, S. and Quintana-Murci, L.
Journal: European Journal of Human Genetics
Issue/Volume: 12(5)
Page(s): 355-364
Year: 2004

Abstract:

The relative roles of natural selection and accentuated genetic drift as explanations for the high frequency of more than 20 Ashkenazi Jewish disease alleles remain controversial. To test for the effects of a maternal bottleneck on the Ashkenazi Jewish population, we performed an extensive analysis of mitochondrial DNA (mtDNA) hypervariable segment 1 (HVS-1) sequence and restriction site polymorphisms in 565 Ashkenazi Jews from different parts of Europe. These patterns of variation were compared with those of five Near Eastern (n=327) and 10 host European (n=849) non-Jewish populations. Only four mtDNA haplogroups (Hgs) (defined on the basis of diagnostic coding region RFLPs and HVS-1 sequence variants) account for 70% of Ashkenazi mtDNA variation. While several Ashkenazi Jewish mtDNA Hgs appear to derive from the Near East, there is also evidence for a low level of introgression from host European non-Jewish populations. HVS-1 sequence analysis revealed increased frequencies of Ashkenazi Jewish haplotypes that are rare or absent in other populations, and a reduced number of singletons in the Ashkenazi Jewish sample. These diversity patterns provide evidence for a prolonged period of low effective size in the history of the Ashkenazi population. The data best fit a model of an early bottleneck (100 generations ago), perhaps corresponding to initial migrations of ancestral Ashkenazim in the Near East or to Europe. A genetic bottleneck followed by the recent phenomenon of rapid population growth are likely to have produced the conditions that led to the high frequency of many genetic disease alleles in the Ashkenazi population.


Source Link: http://dx.doi.org/10.1038/sj.ejhg.5201156

Keywords

Peoples: Ashkenazi Jews | Places: Eastern Europe | Topics: Jewish maternal ancestry | DNA Type: mtDNA

2016-10-27T13:06:50+00:00 December 31st, 2004|