//Deeply divergent archaic mitochondrial genome provides lower time boundary for African gene flow into Neanderthals

Deeply divergent archaic mitochondrial genome provides lower time boundary for African gene flow into Neanderthals

Deeply divergent archaic mitochondrial genome provides lower time boundary for African gene flow into Neanderthals

Author(s): Posth, C., Wißing, C., Kitagawa, K., Pagani, L., van Holstein, L., Racimo, F., Wehrberger, K., Conard, N.J., Kind, C. J., Bocherens, H., & Krause, J.
Journal: Nature Communications
Issue/Volume: 8(16046)
Page(s): -
Year: 2017

Abstract:

Ancient DNA is revealing new insights into the genetic relationship between Pleistocene hominins and modern humans. Nuclear DNA indicated Neanderthals as a sister group of Denisovans after diverging from modern humans. However, the closer affinity of the Neanderthal mitochondrial DNA (mtDNA) to modern humans than Denisovans has recently been suggested as the result of gene flow from an African source into Neanderthals before 100,000 years ago. Here we report the complete mtDNA of an archaic femur from the Hohlenstein–Stadel (HST) cave in southwestern Germany. HST carries the deepest divergent mtDNA lineage that splits from other Neanderthals 270,000 years ago, providing a lower boundary for the time of the putative mtDNA introgression event. We demonstrate that a complete Neanderthal mtDNA replacement is feasible over this time interval even with minimal hominin introgression. The highly divergent HST branch is indicative of greater mtDNA diversity during the Middle Pleistocene than in later periods.


Source Link: https://www.nature.com/articles/ncomms16046

Keywords

Peoples: Neandertals | Places: Germany | Topics: mtDNA | DNA Type: Ancient DNA and mtDNA

2017-07-05T12:02:51+00:00 July 5th, 2017|