//Clustering of 770,000 genomes reveals post-colonial population structure of North America

Clustering of 770,000 genomes reveals post-colonial population structure of North America

Clustering of 770,000 genomes reveals post-colonial population structure of North America

Author(s): Han, E., Carbonetto, P., Curtis, R.E., Wang, Y., Granka, J.M., Byrnes, J., Noto, K., Kermany, A.R., Myres, N.M., Barber, M.J., Rand, K.A., Song, S., Roman, T., Battat, E., Elyashiv, E., Guturu, H., Hong, E.L., Chahine, K.G. & Ball, C.A.
Journal: Nature Communications
Issue/Volume: 8(14238)
Page(s): 14238+
Year: 2017

Abstract:

Despite strides in characterizing human history from genetic polymorphism data, progress in identifying genetic signatures of recent demography has been limited. Here we identify very recent fine-scale population structure in North America from a network of over 500 million genetic (identity-by-descent, IBD) connections among 770,000 genotyped individuals of US origin. We detect densely connected clusters within the network and annotate these clusters using a database of over 20 million genealogical records. Recent population patterns captured by IBD clustering include immigrants such as Scandinavians and French Canadians; groups with continental admixture such as Puerto Ricans; settlers such as the Amish and Appalachians who experienced geographic or cultural isolation; and broad historical trends, including reduced north-south gene flow. Our results yield a detailed historical portrait of North America after European settlement and support substantial genetic heterogeneity in the United States beyond that uncovered by previous studies.


Source Link: http://www.nature.com/articles/ncomms14238

Keywords

Peoples: African Americans and North American | Places: Americas | Topics: IBD | DNA Type: Autosomal DNA

2017-02-08T07:33:32+00:00 February 7th, 2017|