//Analysis of mitochondrial DNA variants in Japanese patients with schizophrenia

Analysis of mitochondrial DNA variants in Japanese patients with schizophrenia

Analysis of mitochondrial DNA variants in Japanese patients with schizophrenia

Author(s): Ueno, H., Nishigaki, Y., Kong, Q.P., Fuku, N., Kojima, S., Iwata, N., Ozaki, N. and Tanaka, M.
Journal: Mitochondrion
Issue/Volume: 9(6)
Page(s): 385-393
Year: 2009

Abstract:

To test the hypothesis that mitochondrial DNA (mtDNA) variants contribute to the susceptibility to schizophrenia, we sequenced the entire mtDNAs from 93 Japanese schizophrenic patients. Three non-synonymous homoplasmic variants in subunit six of the ATP synthase (MT-ATP6) gene that were detected only in patients but not in controls were suggested to be slightly deleterious, because (1) their original amino acid residues (AA) were highly conserved and (2) the physicochemical differences between the original and altered AA were relatively high. In addition, we detected three novel heteroplasmic variants that were potentially pathogenic. Although functional analysis is needed, rare variants in the mtDNA may convey susceptibility to schizophrenia.


Source Link: http://www.sciencedirect.com/science/article/pii/S1567724909001172

Keywords

Peoples: | Places: Japan | Topics: Schizophrenia | DNA Type: mtDNA

2016-08-08T20:56:09+00:00 July 3rd, 2016|