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117 Asian mitochondrial DNA (mtDNA) lineage F4 is associated with increased risk of developing metabolic syndrome

117 Asian mitochondrial DNA (mtDNA) lineage F4 is associated with increased risk of developing metabolic syndrome

Author(s): Lvova, Maria A.; Derbeneva, Olga A.; Chalkia, Dimitra; Chuang, Lee-Ming; Wang, Ping H.; Chang, Yi-Cheng; Mishmar, Dan & Wallace, Douglas
Journal: Mitochondrion
Issue/Volume: 10(2)
Page(s): 233
Year: 2010

Abstract:

Since we first linked mtDNA mutations to Type II diabetes(T2DM) in a family study (Ballinger, S. et al., Nat. Genet. 1, 11–15), increasing evidence has accumulated implicating mtDNA variation in the etiology of T2DM and the metabolic syndrome (MS). Functional mtDNA variation includes both recent inherited mutations but also ancient adaptive polymorphisms encompassed within region-specific mtDNA lineages (haplogroups) (Ruiz-Pesini, E .et al.,2004. Science 303, 223–226). To determine if ancient mtDNA haplogroups might also influence risk for T2DM and MS, we studied 989 subjects from Taiwan which had been evaluated for T2DM & MS. Taiwan was selected because it encompasses a diverse array of Asian mtDNA haplogroups in a population exposed to a high calorie diet. Analysis of this population revealed that haplogroup F4 was strongly associated with obesity including increased waist circumference and BMI. Complete sequencing of several mtDNAs belonging to F4 haplogroup revealed lineage-specific polymorphisms which might contribute to increased risk of obesity. Hence, MS risk can be influenced by ancient regional mtDNA polymorphisms, which might help resolve definitional controversies of MS.


Source Link: http://dx.doi.org/10.1016/j.mito.2009.12.109

Keywords

Peoples: Asians | Places: Asia | Topics: Metabolic syndrome | DNA Type: mtDNA

2016-06-10T08:59:44+00:00 December 31st, 2010|