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Genetic differentiation between upland and lowland populations shapes the Y-chromosomal landscape of West Asia

Here, we analyzed 598 Y-chromosomes from two West Asian subregions—Transcaucasia and the Armenian plateau—using 40 Y-SNPs and 17 Y-STRs and combined them with previously published data from the region.

2017-03-15T12:02:51+00:00 March 14th, 2017|

Mitochondrial DNA diversity in a Transbaikalian Xiongnu population

Here, we analyzed mitochondrial DNA variation in a Transbaikalian Xiongnu population based on ancient DNA obtained from skeletal remains (n = 18) at four burial grounds to complement available Xiongnu genetic diversity data.

2017-03-14T07:39:30+00:00 March 14th, 2017|

Whole-genome view of the consequences of a population bottleneck using 2926 genome sequences from Finland and United Kingdom

As a model of an isolate population, we sequenced the genomes of 1463 Finnish individuals as part of the Sequencing Initiative Suomi (SISu) Project.

2017-02-10T16:18:19+00:00 February 10th, 2017|

Reconstructing the population history of the largest tribe of India: the Dravidian speaking Gond

To gain a more comprehensive view on ancient ancestry and genetic affinities of the Gond with the neighbouring populations speaking Indo-European, Dravidian and Austroasiatic languages, we have studied four geographically distinct groups of Gond using high-resolution data.

2017-02-10T15:59:42+00:00 February 10th, 2017|

A fast and accurate method for detection of IBD shared haplotypes in genome-wide SNP data

We developed a new IBD segment detection program, FISHR (Find IBD Shared Haplotypes Rapidly), in an attempt to accurately detect IBD segments and to better estimate their endpoints using an algorithm that is fast enough to be deployed on very large whole-genome SNP data sets.

2017-02-10T14:40:37+00:00 February 10th, 2017|

Psychological and behavioural impact of returning personal results from whole-genome sequencing: the HealthSeq project

We conducted an exploratory longitudinal cohort study in which quantitative surveys and in-depth qualitative interviews were conducted before and after personal results were returned to individuals who underwent whole-genome sequencing.

2017-02-10T14:04:10+00:00 February 10th, 2017|

Phylogeography of human Y-chromosome haplogroup Q3-L275 from an academic/citizen science collaboration

We analyzed 47 fully sequenced Y-chromosomes and reconstructed the haplogroup Q3 phylogenetic tree in detail. Haplogroup Q3-L275, derived from the oldest known split within Eurasian/American haplogroup Q, most likely occurred in West or Central Asia in the Upper Paleolithic period. During the Mesolithic and Neolithic epochs, Q3 remained a minor component of the West Asian Y-chromosome pool and gave rise to five branches (Q3a to Q3e), which spread across West, Central and parts of South Asia. Around 3–4 millennia ago (Bronze Age), the Q3a branch underwent a rapid expansion, splitting into seven branches, some of which entered Europe. One of these branches, Q3a1, was acquired by a population ancestral to Ashkenazi Jews and grew within this population during the 1st millennium AD, reaching up to 5% in present day Ashkenazi.

2017-02-08T12:22:10+00:00 February 8th, 2017|

Why were Sardinians the shortest Europeans? A journey through genes, infections, nutrition, and sex

The purpose of this review is to focus on the state-of-the-art research on stature, as well as the factors that made Sardinians the shortest among Europeans.

2017-02-07T19:01:45+00:00 February 7th, 2017|

Sex-specific genetic diversity is shaped by cultural factors in Inner Asian human populations

We sampled DNA in Central and Northern Asia from 39 populations of Indo-Iranian and Turkic-Mongolic native speakers. This study highlights that, in Inner Asia, specific cultural behaviors, especially patrilineality and patrilocality, leave a detectable signature on the sex-specific genetic structure.

2017-02-07T16:41:42+00:00 February 7th, 2017|