Differences in genetic structure assessed using Y‐chromosome and mitochondrial DNA markers do not shape the contributions to diversity in African sires

Up to 173 African sires belonging to 11 different subpopulations representative of four cattle groups were analysed for six Y-specific microsatellite loci and a mitochondrial DNA fragment.

2018-01-10T16:19:09+00:00 January 16th, 2018|

Messinian age and savannah environment of the possible hominin Graecopithecus from Europe

For the Graecopithecus-bearing Pikermi Formation of Attica/Greece, a saline aeolian dust deposit of North African (Sahara) provenance, we obtain an age of 7.37–7.11 Ma, which is coeval with a dramatic cooling in the Mediterranean region at the Tortonian-Messinian transition.

2018-02-17T23:26:11+00:00 October 18th, 2017|

Signatures of human European Palaeolithic expansion shown by resequencing of non-recombining X-chromosome segments

This study demonstrates the potential of the use of X-chromosomal haplotype blocks, and the utility of the accurate ascertainment of rare variants for inferring human demographic history.

2017-05-05T11:54:44+00:00 May 5th, 2017|

Updating the African human mitochondrial DNA tree: relevance to forensic and population genetics

We have analyzed >2200 mitogenomes of African ancestry with the aim of improving the known worldwide phylogeny. More than 300 new minor sub-clades were identified, and the Time to the Most Recent Common Ancestor (TMRCA) was estimated for each node of the phylogeny.

2017-01-02T21:08:40+00:00 January 2nd, 2017|

Chad Genetic Diversity Reveals an African History Marked by Multiple Holocene Eurasian Migrations

Here, we use genotype data from 480 samples from Chad, the Near East, and southern Europe, as well as whole-genome sequencing from 19 of them, to show that many populations today derive their genomes from ancient African-Eurasian admixtures.

2016-11-25T10:44:28+00:00 November 25th, 2016|

Selective sweep on human amylase genes postdates the split with Neanderthals

Here we assess amylase copy numbers in a global sample of 480 high coverage genomes and find that regions flanking the amylase locus show notable depression of genetic diversity both in African and non-African populations.

2016-11-24T14:59:21+00:00 November 24th, 2016|

A recent bottleneck of Y chromosome diversity coincides with a global change in culture

Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192–307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47–52 kya...

2016-12-11T19:07:50+00:00 October 28th, 2016|

A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome

Here we present genetic variation from deeply sequenced genomes of 642 individuals from North and South American, Caribbean and West African populations, substantially increasing the lexicon of human genomic variation and suggesting much variation remains to be discovered in African-admixed populations in the Americas.

2016-10-14T21:40:35+00:00 October 14th, 2016|

The African Genome Variation Project shapes medical genetics in Africa

Given the importance of Africa to studies of human origins and disease susceptibility, detailed characterization of African genetic diversity is needed. The African Genome Variation Project provides a resource with which to design, implement and interpret genomic studies in sub-Saharan Africa and worldwide. The African Genome Variation Project represents dense genotypes from 1,481 individuals and whole-genome sequences from 320 individuals across sub-Saharan Africa.

2016-07-16T14:46:08+00:00 July 16th, 2016|

MtDNA analysis of global populations support that major population expansions began before Neolithic Time

Agriculture resulted in extensive population growths and human activities. However, whether major human expansions started after Neolithic Time still remained controversial. With the benefit of 1000 Genome Project, we were able to analyze a total of 910 samples from 11 populations in Africa, Europe and Americas.

2016-07-01T21:58:12+00:00 July 1st, 2016|