The finding of disaccord in haplogroup prediction by online software in a father-son pair

Although Y-STR typing seems more widely used in forensic casework and convenient to predict haplogroup with online tools, our finding suggested that the occurrence of errors in Y-chromosome haplogroup prediction should be cautious.

2017-09-19T08:43:28+00:00 September 19th, 2017|

Comprehensive Mutation Analysis of 53 Y-STR Markers in Father-Son Pairs

The knowledge of mutation rate at Y-STR markers is essential in forensic casework, especially kinship genetic studies. In the present study, one hundred father–son pairs from Chinese Han population were typed with 53 Y STR markers (38 conventional markers and 15 rapidly mutating markers).

2017-09-16T18:53:04+00:00 September 16th, 2017|

Deep sequencing shows that oocytes are not prone to accumulate mtDNA heteroplasmic mutations during ovarian ageing

The alteration of mtDNA integrity in oocytes during ovarian ageing is a recurring question to which our pilot study suggests a reassuring answer.

2017-09-05T16:17:02+00:00 September 5th, 2017|

The distribution of mitochondrial DNA haplogroup H in southern Iberia indicates ancient human genetic exchanges along the western edge of the Mediterranean

Derived haplotypes were found in both regions; haplotypes were shared far more frequently between Andalusia and Morocco than between Andalusia and the rest of the Maghreb. These and previous results indicate intense, ancient and sustained contact among populations on both sides of the Mediterranean.

2017-08-04T09:51:11+00:00 August 4th, 2017|

Fast STR allele identification with STRait Razor 3.0

STRait Razor v3.0 performs ∼660 x faster allele identification than its previous version (v2s), a speedup that is largely due to a novel indexing strategy used to perform “fuzzy” (approximate) string matching of anchor sequences. Written in a portable compiled language, C + +, STRait Razor v3.0 functions on all major operating systems including Microsoft Windows, and it has cross-platform multithreading support.

2017-06-07T18:56:50+00:00 June 6th, 2017|

Paternity testing under the cloak of recreational genetics

Direct-to-consumer (DTC) internet companies are selling widely advertised and highly popular genetic ancestry tests to the broad public. These tests are often classified as falling within the scope of so-called ‘recreational genetics’, but...

2017-04-14T20:10:14+00:00 April 14th, 2017|