//Mitochondrion

Mitochondrion

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Articles of Interest

Cultural diffusion of Indo-Aryan languages into Bangladesh: A perspective from mitochondrial DNA

Journal: Mitochondrion | Year: 2017

Abstract:

Although both linguistic and historical studies indicated only a small group of Aryans had been involved into the diffusion of Indo-Aryan languages into Bangladesh, no genetic studies had been carried out to prove this notion. By studying mitochondrial DNA variants of 240 Bengali speakers in Bangladesh, among which 23 mitogenomes are completely sequenced, we found a high proportion of South Asian components in this group. By contrast, only a small proportion of lineages can be traced back to western Eurasia, which could be attributed to recent gene flow. Our results implied a cultural diffusion of the Indo-Aryan languages into Bangladesh.

Peoples: Aryans | Places: Bangladesh | Topics: Indo-Aryan languages | DNA Type: mtDNA

The novel G10680A mutation is associated with complete penetrance of the LHON/T14484C family

Journal: Mitochondrion | Year: 2009

Abstract:

Peoples: | Places: | Topics: | DNA Type: mtDNA

Hereditary spastic paraplegia-like disorder due to a mitochondrial ATP6 gene point mutation

Journal: Mitochondrion | Year: 2011

Abstract:

Peoples: | Places: | Topics: | DNA Type: mtDNA

Analysis of mitochondrial DNA variants in Japanese patients with schizophrenia

Journal: Mitochondrion | Year: 2009

Abstract:

To test the hypothesis that mitochondrial DNA (mtDNA) variants contribute to the susceptibility to schizophrenia, we sequenced the entire mtDNAs from 93 Japanese schizophrenic patients. Three non-synonymous homoplasmic variants in subunit six of the ATP synthase (MT-ATP6) gene that were detected only in patients but not in controls were suggested to be slightly deleterious, because (1) their original amino acid residues (AA) were highly conserved and (2) the physicochemical differences between the original and altered AA were relatively high. In addition, we detected three novel heteroplasmic variants that were potentially pathogenic. Although functional analysis is needed, rare variants in the mtDNA may convey susceptibility to schizophrenia.

Peoples: | Places: Japan | Topics: Schizophrenia | DNA Type: mtDNA

Mitochondrial DNA haplogroup ‘R’ is associated with Noonan syndrome of South India

Journal: Mitochondrion | Year: 2010

Abstract:

Peoples: | Places: | Topics: | DNA Type: mtDNA

Ethambutol-induced optic neuropathy linked to OPA1 mutation and mitochondrial toxicity

Journal: Mitochondrion | Year: 2010

Abstract:

Peoples: | Places: | Topics: | DNA Type: mtDNA

Mitochondrial dysfunction and genetic heterogeneity in chronic periodontitis

Journal: Mitochondrion | Year: 2011

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Peoples: | Places: | Topics: | DNA Type: mtDNA

Analysis of mitochondrial genome revealed a rare 50 bp deletion and substitutions in a family with hypertension

Journal: Mitochondrion | Year: 2011

Abstract:

Peoples: | Places: | Topics: | DNA Type: mtDNA

MitoTool: a web server for the analysis and retrieval of human mitochondrial DNA sequence variations

Journal: Mitochondrion | Year: 2011

Abstract:

MitoTool, a web-based bioinformatics platform, is designed for deciphering human mitochondrial DNA (mtDNA) data in batch mode. The platform has advantages in (i) parsing diverse types of mtDNA data; (ii) automatically classifying haplogroup according to mtDNA sequences or variants; (iii) discovering possibly missing variants of the samples with claimed haplogroups status; (iv) estimating the evolutionary conservation index, protein coding effect and potential pathogenicity of certain substitutions; (v) performing statistical analysis for haplogroup distribution frequency between case and control groups. Furthermore, it offers an integrated database for retrieving five types of mitochondrion-related information. The MitoTool is freely accessed at http://www.mitotool.org.

Peoples: | Places: | Topics: | DNA Type: mtDNA

An update to MitoTool: using a new scoring system for faster mtDNA haplogroup determination

Journal: Mitochondrion | Year: 2013

Abstract:

The prominent properties of mtDNA such as maternal inheritance, absence of recombination and the high mutation rate make this molecule widely used in population genetics, forensics and medical genetics. Meanwhile, the assignment of mtDNA into haplogroups has become a routine analysis (even a critical prerequisite in the forensic field), which helps researchers to (i) conduct an a posteriori quality control of data, as this recommended analysis is beneficial for detecting five major types of errors in mtDNA data, including base shifts, reference bias, phantom mutations, base misscoring and artefactual recombination ( Bandelt et al., 2001); and (ii) avoid potential pitfalls in mtDNA disease studies ( Yao et al., 2006 and Yao et al., 2009). However, traditional manual haplogroup determination is a daunting task, especially when MitoChip (Maitra et al., 2004) and high throughput next-generation sequencing technologies (Gunnarsdottir et al., 2011) are employed, as these produce a huge amount of mtDNA data. Furthermore, with the aim to provide the most up-to-date version of the mtDNA classification system and avoid some possible conflicts, the mtDNA tree at www.phylotree.org (van Oven and Kayser, 2009) is revised regularly. For the beginner who is not familiar with manual haplogroup determination, the continually expanding mtDNA tree and size of datasets make haplogroup determination ever more challenging.

Peoples: | Places: | Topics: | DNA Type: mtDNA

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2005-01-01T00:00:00+00:00 January 1st, 2005|